PD-L1 antibody should be stored in working aliquots at -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Dry Ice:
This product requires shipping in dry ice and an additional shipping charge will be made.
Target Species:
Human
Product Type:
Single Domain Antibodies
Description:
Conjugate: UnconjugatedPurification: PD-L1 Antibody is affinity chromatography purified via Nickel column.Specificity: At least three isoforms of PD-L1 are known to exist.Immunogen: PD-L1 antibody was raised against a recombinant protein corresponding to amino acids 19 - 239 of human PD-L1.Application: PD-L1 antibody can be used for detection of PD-L1 by ELISA and ICC (10 μg/ml).Buffer: PD-L1 Antibody is supplied in PBS containing 0.02% sodium azide.Concentration: 1 mg/mL
Supplier:
ProSci
Product Category:
Cancer & Cell Proliferation > Immune Checkpoints
PD-L1 Antibody: Cell-mediated immune responses are initiated by T lymphocytes that are themselves stimulated by cognate peptides bound to MHC molecules on antigen-presenting cells (APC). T-cell activation is generally self-limited as activated T cells express receptors such as PD-1 (also known as PDCD-1) that mediate inhibitory signals from the APC. PD-1 can bind two different but related ligands, PD-L1 and PD-L2. PD-L1 is a B7-related protein that inhibits cell-mediated immune responses by reducing the secretion of IL-2 and IL-10 from memory T cells. This suggests that PD-L1 may be useful in reducing allogenic CD4+ memory T-cell responses to endothelial cells, thereby reducing the likelihood of host immune responses to allografts.